Bring hospital into home toward controlling inflammation at home
Moonshot Research and Development Program [Goal 7]
Realization of sustainable care systems to overcome major diseases by 2040, for enjoying one’s life with relief and release from health concerns until 100 years old.
Project
Theme Ⅰ: Elucidating the putative mechanisms through which exercise controls inflammation and exploring innovative biomarkers for inflammation
Lack of exercise causes lifestyle-related diseases, and conversely, exercise is a good preventive and therapeutic method for these diseases. We aim to establish exercise biomarkers by analysizing physiologically active substances that are secreted from the locomotory organs (muscles and bones) through exercise to regurate systemic metabolism of the entire body and are also related to the inflammation control.
Theme Ⅱ: Exploring the link between sleep and inflammation and Development of personalized digital health
We aim to explore the linkage between sleep and inflammation control and develop digital health that can respond to individualized needs, and construct lifestyle biomarkers and other inflammation control. We will explore the possibility of individualized feedback of inflammation control by understanding the correlation between sleep and exercise.
Theme Ⅲ: Development of innovative inflammation sensing technology and establishment of inflammation indexes for the numerical assessment of inflammation
Body gases (mainly skin gases) can be evaluated non-invasively and are useful for remote biological monitoring. We aim to develop super-sensitive sensing technology for body gas to detect inflammatory biomarkers that may cause diseases, and establish an inflammation index that quantifies inflammation. Furthermore, we aim to develop a compact super-sensitive skin gas sensor that can be worn at all times and used repeatedly.
Theme Ⅳ: Establishment of inflammation controlling medical technology for evoking "regulated inflammation"
We aim to develop a method of inducing "controlled inflammation" through electrical stimulation devices and exercise-mimicking drugs as a means of controlling inflammation, and ensure that the solutions are available to all citizens including the "physically weak" who are unable to secure opportunities for exercise.
Theme Ⅴ: Development of innovative technology for next-generatoin diagnostic tests to bring hospital into home
We will develop a new digital analysis method for measuring exercise biomarkers at home; develop a next-generation digital bioanalytical method by advancing the Digital Bioanalytical Method, which is a new bioanalytical technology with single molecule sensitivity. We will develop a portable and inexpensive next-generation digital bioanalytical technology (Digital Bio 2.0) by developing a reactor with active functions that has a molecular concentration function in the reactor itself. Furthermore, we aim to develop a sampling and processing method for specimens that is as non-invasive as possible in trace amounts. By integrating these methods, we will establish portable digital bioanalysis.
Theme Ⅵ: Design and implementation of real-time data management system based on FHIR for healthcare services: improving interoperability in health data
We aim to connect the sensing devices developed in Themes 1-5 with the living area data collection system, and build a network between these devices and the next-generation telehealth system.